Comparison of gene expression profiles in granulosa and cumulus cells after ovulation induction with either human chorionic gonadotropin or a gonadotropin-releasing hormone agonist trigger

What Was Tested

The paper reports a study of hCG (human chorionic gonadotropin) and Buserelin, published as a randomized controlled trial.

To explore differences in follicle transcriptomes in patients having oocyte maturation with either a bolus of hCG or GnRHa.

Who Took Part

PubMed tags the participants as women only.

Cumulus cells (CC) and mural granulosa cells (MGC) were isolated from preovulatory follicles in patients undergoing controlled ovarian stimulation, prospectively randomized to GnRHa or hCG triggering.

Twenty women with indication for IVF or intracytoplasmic sperm injection treatment were randomly allocated to hCG or GnRH agonist (GnRHa) trigger.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got hCG (human chorionic gonadotropin) and who got the comparison, which limits bias.

University-based facilities for clinical services and research.

MGC and CC were collected from individual follicles in connection with oocyte retrieval.

What Was Measured

Topics PubMed links to this paper include Buserelin, Chorionic Gonadotropin, Cumulus Cells, Denmark, Fertility Agents, Female, Gene Expression Profiling and Gene Expression Regulation, Developmental.

Author keywords: GnRHa trigger, gene expression profile, granulosa cells and hCG trigger.

What This Means in Plain Language

The paper is a randomized study of hCG (human chorionic gonadotropin) and Buserelin.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2013 (Fertility and sterility), a journal based in United States.

More context: the hCG (human chorionic gonadotropin) compound page and the Buserelin compound page, all human trials.