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In healthy adults, biological activity of vitamin D, as assessed by serum PTH, is largely independent of DBP concentrations.
Plain-language guide to PMID 23857798 (2014): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 2073 subjects.
Key Facts
- PMID
- 23857798
- Journal
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Dastani Z et al. (9 authors)
- DOI
- 10.1002/jbmr.2042
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The impact of circulating DBP levels on vitamin D's biologic action, is unclear, but is of particular relevance to vitamin D epidemiology, because a lack of control for DBP levels could strongly influence the association of vitamin D with disease.
Serum parathyroid hormone (PTH) levels can act as a biological readout of 25(OH)D activity.
Who Took Part
The study group was 2073 subjects.
By PubMed's age tags, the people studied were teenagers, adults, middle-aged adults, older adults and people over 80, both men and women.
How the Study Was Run
The researchers set it up as a randomized study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
What Was Measured
The impact of circulating DBP levels on vitamin D's biologic action, is unclear, but is of particular relevance to vitamin D epidemiology, because a lack of control for DBP levels could strongly influence the association of vitamin D with disease.
Serum parathyroid hormone (PTH) levels can act as a biological readout of 25(OH)D activity.
The subject headings attached to it are Age Factors, Body Mass Index, Parathyroid Hormone, Vitamin D and Vitamin D-Binding Protein.
The authors tagged it with the keywords PTH, VITAMIN D BINDING PROTEIN (DBP) and VITAMIN D CONCENTRATION.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 2073 subjects.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2014 (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.