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Increased anxiety induced by listening to unpleasant music during stress exposure is associated with reduced blood pressure and ACTH responses in healthy men
Plain-language guide to PMID 23860406 (2013): crossover randomized controlled trial study of ACTH (Corticotropin) in 14 volunteers, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 23860406
- Journal
- Neuroendocrinology
- Year
- 2013
- Study type
- Randomized Controlled Trial
- Authors
- Jezova D et al. (6 authors)
- DOI
- 10.1159/000354202
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at ACTH (Corticotropin) in the context of low blood pressure and orthostatic hypotension.
The researchers decided to examine the effects of listening to music on anxiety and to apply a new methodological approach.
Why It Was Studied
The relationship between anxiety and the neuroendocrine response to stress stimuli is still not fully understood.
To do so, it was necessary to find a stress condition of the same character and intensity with and without a rise in state anxiety.
Who Took Part
The study group was 14 volunteers.
By PubMed's age tags, the people studied were young adults and adults, men only.
How the Study Was Run
The researchers set it up as a randomized and crossover study.
The volunteers were allocated by chance, so the ACTH (Corticotropin) group and the comparison group should start out alike.
In the crossover set-up each of the volunteers took both ACTH (Corticotropin) and the comparison in turn, acting as their own control.
What Was Measured
The stress procedure consisted of mental (Stroop test, mental arithmetic) and physical (handgrip exercise) tasks combined with listening to music played forward (pleasant) or backwards (unpleasant).
PubMed files the paper under topics including Adrenocorticotropic Hormone, Anxiety, Blood Pressure, Epinephrine, Exercise Test, Hand Strength and Health.
What This Means in Plain Language
The paper is a randomized and crossover study of ACTH (Corticotropin) in 14 volunteers in people with low blood pressure and orthostatic hypotension.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2013 (Neuroendocrinology), a journal based in Switzerland.
More context: the ACTH (Corticotropin) compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.