Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Who Took Part

According to the abstract, 107 patients were involved.

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and pilot study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.

The primary outcome measures were pain and function, and the secondary were biochemical markers.

At baseline, the two groups were comparable.

What Was Measured

Topics PubMed links to this paper include Alkaline Phosphatase, Arthralgia, Biomarkers, Biomechanical Phenomena, Calcium, Chi-Square Distribution and Dietary Supplements.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 107 patients.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2013 (Clinical orthopaedics and related research), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.