Effect of partial gastrectomy with Billroth II or Roux-en-Y anastomosis on postprandial and cholecystokinin-stimulated gallbladder contraction and secretion of cholecystokinin and pancreatic polypeptide

What Was Tested

The paper reports a study of Pancreatic Polypeptide and Cholecystokinin (CCK), published as a randomized controlled trial.

This prospective study was undertaken to determine the effect of partial gastrectomy without vagotomy on postprandial gallbladder contraction and secretion of cholecystokinin (CCK) and pancreatic polypeptide (PP) in 22 peptic ulcer patients randomly assigned to either Billroth II (N = 11) or Roux-en-Y (N = 11) anastomosis.

Why It Was Studied

After surgery basal gallbladder volumes were larger than preoperatively (P less than 0.02).

Who Took Part

The study group was 22 patients.

The age groups tagged for this paper are middle-aged adults, both men and women.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Pancreatic Polypeptide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The methods mention a period of two weeks.

What Was Measured

Topics PubMed links to this paper include Anastomosis, Roux-en-Y, Cholecystokinin, Cholelithiasis, Food, Gallbladder, Gastrectomy and Jejunum.

What This Means in Plain Language

The paper is a randomized study of Pancreatic Polypeptide and Cholecystokinin (CCK) in 22 patients over two weeks.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1990 (Digestive diseases and sciences), a journal based in United States.

More context: the Pancreatic Polypeptide compound page and the Cholecystokinin (CCK) compound page, all human trials.