Neodymium-yttrium aluminum garnet laser versus pulsed dye laser in erythemato-telangiectatic rosacea: comparison of clinical efficacy and effect on cutaneous substance (P) expression

What Was Tested

Researchers studied Substance P in the context of rosacea in this controlled clinical trial publication.

To compare the effect of Nd-YAG laser and PDL on erythemato-telangiectatic rosacea, both clinically and immunohistochemically on cutaneous substance (P) expression.

Why It Was Studied

Substance (P) is implicated in rosacea pathogenesis.

Who Took Part

The study group was 15 patients.

By PubMed's age tags, the people studied were adults and middle-aged adults, women only.

This split-face comparative study included 15 patients with erythemato-telangiectatic rosacea treated on the right side with Nd-YAG laser and on the left side with PDL: three sessions, 4 weeks apart.

Evaluation of the patients was done using erythema and telangiectasia grading scores, patient's self-assessment, physicians' clinical assessment of the patient, and immunohistochemical assessment of substance (P).

What Was Measured

PubMed files the paper under topics including Erythema, Lasers, Dye, Lasers, Solid-State, Rosacea, Substance P and Telangiectasis.

The authors tagged it with the keywords Nd-YAG, Neodymium-yttrium aluminum garnet laser, PDL, pulsed dye laser and substance (P).

What This Means in Plain Language

This is a controlled clinical trial of Substance P in 15 patients in people with rosacea.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2013 (Journal of cosmetic dermatology), a journal based in England.

More context: the Substance P compound page, Rosacea research.