Maternal vitamin D3 supplementation during the third trimester of pregnancy: effects on infant growth in a longitudinal follow-up study in Bangladesh.

Plain-language guide to PMID 23998516 (2013): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84).

Key Facts

PMID: 23998516
Journal: The Journal of pediatrics
Year: 2013
Study type: Randomized Controlled Trial
Authors: Roth DE et al. (4 authors)
DOI: 10.1016/j.jpeds.2013.07.030
Registered trial: NCT01126528

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84) in this randomized controlled trial publication.

To estimate the effects of prenatal vitamin D supplementation on infant growth in Dhaka, Bangladesh.

Who Took Part

By PubMed's age tags, the people studied were infants, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Anthropometry was performed at birth, 1, 2, 4, 6, 9, and 12 months of age.

The primary analysis (n = 145 overall; n = 134 at 1 year) was a comparison of mean length-for-age z-score (LAZ) based on World Health Organization standards.

What Was Measured

Topics PubMed links to this paper include Bangladesh, Child Development, Cholecalciferol, Dietary Supplements, Growth, Longitudinal Studies and Pregnancy Complications.

The authors tagged it with the keywords 25(OH)D, 25-hydroxyvitamin D, AViDD, Antenatal vitamin D in Dhaka, HCAZ and Head circumference-for-age z-score.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84).

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2013 (The Journal of pediatrics), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Parathyroid Hormone (PTH 1-84) compound page, all human trials.

Our Notes on the Compounds

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.