Gonadal steroids and body composition, strength, and sexual function in men

What Was Tested

This randomized controlled trial paper looks at Goserelin in the context of sexual function & libido (women and men).

Current approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various testosterone levels or whether deficiencies of testosterone, estradiol, or both account for clinical manifestations.

Who Took Part

The study group was 198 men.

By PubMed's age tags, the people studied were young adults, adults and middle-aged adults, men only.

Another 202 healthy men received goserelin acetate, placebo gel or testosterone gel, and anastrozole (to suppress the conversion of testosterone to estradiol).

How the Study Was Run

The design is described as randomized and placebo-controlled.

Because people in this Goserelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some men received a placebo instead of Goserelin, giving a reference point.

Changes in the percentage of body fat and in lean mass were the primary outcomes.

Subcutaneous- and intraabdominal-fat areas, thigh-muscle area and strength, and sexual function were also assessed.

What Was Measured

Current approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various testosterone levels or whether deficiencies of testosterone, estradiol, or both account for clinical manifestations.

Topics PubMed links to this paper include Adipose Tissue, Aromatase Inhibitors, Body Composition, Estradiol, Goserelin, Libido and Muscle Strength.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Goserelin in 198 men in people with sexual function & libido (women and men).

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2013 (The New England journal of medicine), a journal based in United States.

More context: the Goserelin compound page, Sexual function & libido (women and men) research.