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Increased active PTH(1-84) fraction as a predictor of poor mortality in male hemodialysis patients
Plain-language guide to PMID 24030285 (2013): observational study of Parathyroid Hormone (PTH 1-84) in 177 patients.
Key Facts
- PMID
- 24030285
- Journal
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- Year
- 2013
- Study type
- Observational Study
- Authors
- Inaba M et al. (6 authors)
- DOI
- 10.1007/s00198-012-2245-x
What This Study Did, in Plain Language
What Was Tested
Researchers studied Parathyroid Hormone (PTH 1-84) in this observational study publication.
The purpose of their study was to investigate the association of PTH(1-84)/intact PTH ratio with all-cause mortality (ACM) in male hemodialysis patients.
Why It Was Studied
The researchers reported previously that serum parathyroid hormone [PTH(1-84)]/intact PTH[PTH(1-84) + PTH(7-84)] ratio provides the better marker for parathyroid function and bone turnover state than serum PTH level itself.
The researchers reported that PTH(1-84)/intact PTH ratio provides a clinically relevant marker for parathyroid function and the resultant bone turnover state.
Who Took Part
The study group was 177 patients.
PubMed indexes the participants as middle-aged adults and older adults, men only.
Serum PTH in 177 male hemodialysis patients was measured with PTH(1-84)-specific whole PTH assay and intact PTH assay which cross-reacts with N-truncated PTH including PTH(7-84).
What Was Measured
The researchers reported previously that serum parathyroid hormone [PTH(1-84)]/intact PTH[PTH(1-84) + PTH(7-84)] ratio provides the better marker for parathyroid function and bone turnover state than serum PTH level itself.
PubMed files the paper under topics including Biomarkers, Cholecalciferol, Japan, Kaplan-Meier Estimate, Kidney Failure, Chronic, Parathyroid Hormone and Peptide Fragments.
What This Means in Plain Language
This is an observational study of Parathyroid Hormone (PTH 1-84) in 177 patients.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2013 (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA), a journal based in England.
More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.