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Calcium and vitamin d supplementation in postmenopausal women.
Plain-language guide to PMID 24064695 (2013): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 159 women.
Key Facts
- PMID
- 24064695
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 2013
- Study type
- Randomized Controlled Trial
- Authors
- Aloia JF et al. (6 authors)
- DOI
- 10.1210/jc.2013-2121
- Registered trial
- NCT00762775
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
Their objective was to evaluate the influence of calcium and vitamin D supplementation on PTH and bone turnover.
SETTING, PATIENTS, AND DESIGN: At an ambulatory research center, 159 postmenopausal healthy white women participated in this double-blind, placebo-controlled parallel, longitudinal factorial study that was 6 months in duration.
Why It Was Studied
Bone health is influenced by the intake of both calcium and vitamin D.
Who Took Part
The study group was 159 women.
By PubMed's age tags, the people studied were middle-aged adults and older adults, women only.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and parallel-group study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
Some women received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.
Serum and urine were collected fasting and 2 hours after a calcium load at baseline and at 3 and 6 months.
What Was Measured
Topics PubMed links to this paper include Bone Remodeling, Bone and Bones, Calcium, Calcium, Dietary, Cholecalciferol, Collagen Type I and Dietary Supplements.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 159 women.
Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2013 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.