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Effect of acute and regular exercise on growth hormone secretagogue receptor-1a expression in human lymphocytes, T cell subpopulation and monocytes.

Plain-language guide to PMID 24095896 (2014): crossover randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and Ghrelin.

Key Facts

PMID
24095896
Journal
Brain, behavior, and immunity
Year
2014
Study type
Randomized Controlled Trial
Authors
Bishop NC et al. (6 authors)
DOI
10.1016/j.bbi.2013.09.017

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and Ghrelin.

The aim of this study was to determine the effect of acute exercise on GHS-R1a expression on circulating CD14+ monocytes, total lymphocytes and CD3+ T cells.

Why It Was Studied

The orexigenic peptide hormone ghrelin exerts potent inhibitory effects on pro-inflammatory cytokine release via the growth hormone secretagogue receptor-1a (GHS-R1a) on T cells and monocytes.

Who Took Part

The age groups tagged for this paper are young adults and adults, men only.

How the Study Was Run

The design is described as randomized and crossover.

Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In the crossover set-up each of the participants took both Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison in turn, acting as their own control.

What Was Measured

PubMed files the paper under topics including CD3 Complex, Exercise, Ghrelin, Lipopolysaccharide Receptors, Lymphocytes, Monocytes and Receptors, Ghrelin.

Author keywords: Growth hormone secretagogue receptor, Inflammatory and T cell.

What This Means in Plain Language

The paper is a randomized and crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and Ghrelin.

The publication is from 2014 (Brain, behavior, and immunity), a journal based in Netherlands.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the Ghrelin compound page, all human trials.

Our Notes on the Compounds

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.