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Effect of treatment of vitamin D deficiency and insufficiency during pregnancy on fetal growth indices and maternal weight gain: a randomized clinical trial.
Plain-language guide to PMID 24210789 (2014): open-label randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 130 women.
Key Facts
- PMID
- 24210789
- Journal
- European journal of obstetrics, gynecology, and reproductive biology
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Hashemipour S et al. (7 authors)
- DOI
- 10.1016/j.ejogrb.2013.10.010
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
A multivariate regression analysis was performed to examine the independent effect of maternal vitamin D level on fetal growth indices.
Who Took Part
According to the abstract, 130 women were involved.
PubMed indexes the participants as young adults and adults, women only.
In this open-label randomized clinical trial, 130 Iranian pregnant women (24-26 weeks of gestation) with vitamin D deficiency or insufficiency [25(OH)D <30ng/ml] were divided at random into an intervention group and a control group.
How the Study Was Run
The researchers set it up as a randomized and open-label study.
The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Nothing was hidden in this open-label Vitamin D, K2, Magnesium and Zinc study: the women and staff both knew the treatment.
At delivery, maternal and cord blood 25(OH)D levels, maternal weight gain, neonatal length, neonatal weight and neonatal head circumference were compared between two groups.
Serum vitamin D was measured using enzyme-linked immunosorbent assay.
What Was Measured
PubMed files the paper under topics including Birth Weight, Body Height, Calcium, Cholecalciferol, Fetal Development, Iran and Multivariate Analysis.
Author keywords: Fetal growth, Pregnancy and Vitamin D deficiency.
What This Means in Plain Language
The paper is a randomized and open-label study of Vitamin D, K2, Magnesium and Zinc in 130 women.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2014 (European journal of obstetrics, gynecology, and reproductive biology), a journal based in Ireland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.