A prospective double blind study comparing the effects of oxytocin and human chorionic gonadotrophin as trigger for ovulation

What Was Tested

Researchers studied hCG (human chorionic gonadotropin) and Oxytocin in this randomized controlled trial publication.

This study was undertaken to compare the effect of oxytocin and human chorionic gonadotrophin (hCG) on ovulation and conception.

Why It Was Studied

The size and number of follicles by transvaginal sonography determined the administration of hCG or oxytocin.

The ovulation and pregnancy rate of the two groups were compared.

Who Took Part

The study group was 100 women.

The age groups tagged for this paper are adults, women only.

A total of 100 women with anovulatory infertility were allocated into two equal groups to take clomiphene citrate plus hCG or clomiphene citrate plus oxytocin.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Random assignment meant chance, not the researchers, decided who got hCG (human chorionic gonadotropin) and who got the comparison, which limits bias.

As a double-blind hCG (human chorionic gonadotropin) study, the assignments were hidden from both participants and investigators until the end.

The serum progesterone concentration was measured to provide evidence for ovulation.

What Was Measured

Topics PubMed links to this paper include Anovulation, Chorionic Gonadotropin, Ovulation Induction, Oxytocin, Pregnancy Rate and Reproductive Control Agents.

What This Means in Plain Language

The paper is a randomized and double-blind study of hCG (human chorionic gonadotropin) and Oxytocin in 100 women.

The publication is from 2014 (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology), a journal based in England.

More context: the hCG (human chorionic gonadotropin) compound page and the Oxytocin compound page, all human trials.