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Reduction in the incidence of acute kidney injury after aortic arch surgery with low-dose atrial natriuretic peptide: a randomised controlled trial
Plain-language guide to PMID 24384584 (2014): double-blind randomized controlled trial study of ANP (Atrial Natriuretic Peptide).
Key Facts
- PMID
- 24384584
- Journal
- European journal of anaesthesiology
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Mori Y et al. (3 authors)
- DOI
- 10.1097/EJA.0000000000000035
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at ANP (Atrial Natriuretic Peptide).
Atrial natriuretic peptide (ANP) dilates the preglomerular renal arteries and inhibits the renin-angiotensin axis.
Kawasaki ANP trial, UMIN Clinical Trials Registry ID: UMIN000011650.
Who Took Part
The age groups tagged for this paper are adults, middle-aged adults, older adults and people over 80, men only.
Forty-two patients with normal preoperative renal function undergoing elective repair of an aortic arch aneurysm.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Because people in this ANP (Atrial Natriuretic Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind ANP (Atrial Natriuretic Peptide) study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the ANP (Atrial Natriuretic Peptide) group a baseline to be compared against.
Operating room and intensive care unit at Kawasaki Saiwai Hospital, Kanagawa, Japan.
The infusion was started after induction of anaesthesia and continued for 24 h postoperatively.
What Was Measured
Topics PubMed links to this paper include Acute Kidney Injury, Aortic Aneurysm, Thoracic, Arterial Pressure, Atrial Natriuretic Factor, Circulatory Arrest, Deep Hypothermia Induced, Incidence and Japan.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of ANP (Atrial Natriuretic Peptide).
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2014 (European journal of anaesthesiology), a journal based in England.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.