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Effect of zinc supplementation on inflammatory markers and adipokines in young obese women.
Plain-language guide to PMID 24402636 (2014): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 20 women.
Key Facts
- PMID
- 24402636
- Journal
- Biological trace element research
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Kim J et al. (2 authors)
- DOI
- 10.1007/s12011-013-9885-3
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The study explored the effect of zinc supplementation on inflammatory markers and adipocyte hormones in young obese women.
Usual dietary zinc intake was estimated from 3-day diet records.
Who Took Part
The abstract describes 20 women taking part.
By PubMed's age tags, the people studied were young adults and adults, women only.
Twenty five non-obese women and forty obese women (body mass index ≥25 kg/m(2)) aged 19-28 years were recruited for this study.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the women and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
Serum zinc and urinary zinc concentration were measured by Atomic Absorption Spectrophotometry.
Inflammatory markers such as high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), and interleukin (IL)-6 and adipocyte hormones such as lepin and adiponectin were measured by enzyme immunoassay.
What Was Measured
The subject headings attached to it are Adipokines, Biomarkers, Body Mass Index, C-Reactive Protein, Cytokines, Dietary Supplements and Interleukin-6.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 20 women.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2014 (Biological trace element research), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.