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Intranasal angiotensin II in humans reduces blood pressure when angiotensin II type 1 receptors are blocked
Plain-language guide to PMID 24420549 (2014): double-blind randomized controlled trial study of Angiotensin II, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 24420549
- Journal
- Hypertension (Dallas, Tex. : 1979)
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Derad I et al. (6 authors)
- DOI
- 10.1161/HYPERTENSIONAHA.113.02860
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Angiotensin II in the context of low blood pressure and orthostatic hypotension.
Intranasal administration of angiotensin II (ANGII) affects blood pressure in a mode different from intravenously administered ANGII via a direct access to the brain bypassing the blood-brain barrier.
This clinical study investigated blood pressure regulation after intranasal ANGII administration in healthy humans, whereas systemic, blood-mediated effects of ANGII were specifically blocked.
Who Took Part
By PubMed's age tags, the people studied were adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and crossover.
The participants were allocated by chance, so the Angiotensin II group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Angiotensin II, so expectations could not easily colour the readings.
Some participants received a placebo instead of Angiotensin II, giving a reference point.
In the crossover set-up each of the participants took both Angiotensin II and the comparison in turn, acting as their own control.
Plasma levels of ANGII, aldosterone, renin, vasopressin, and norepinephrine were measured; blood pressure and heart rate were recorded continuously.
What Was Measured
Plasma levels of vasopressin and norepinephrine remained unaffected.
The subject headings attached to it are Aldosterone, Angiotensin II, Angiotensin II Type 1 Receptor Blockers, Blood Pressure, Heart Rate, Hydrocortisone and Receptor, Angiotensin, Type 1.
Author keywords: administration, intranasal and central nervous system.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Angiotensin II in people with low blood pressure and orthostatic hypotension.
The publication is from 2014 (Hypertension (Dallas, Tex. : 1979)), a journal based in United States.
More context: the Angiotensin II compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.