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Detection and effects on serum and urine steroid and LH of repeated GnRH analog (leuprolide) stimulation
Plain-language guide to PMID 24495617 (2014): open-label randomized controlled trial study of Leuprolide.
Key Facts
- PMID
- 24495617
- Journal
- The Journal of steroid biochemistry and molecular biology
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Handelsman DJ et al. (6 authors)
- DOI
- 10.1016/j.jsbmb.2014.01.011
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Leuprolide.
This study aimed to determine if (a) stimulation for 5 days by leuprolide (a superactive GnRH analog) of serum and urine steroids and urine LH is reproducible at a 2 week interval, (b) nandrolone decanoate (ND) co-administration masks responses to leuprolide administration, (c) performance of urine measurement of leuprolide and M1, its major metabolite, as a detection test.
Why It Was Studied
While superactive GnRH analog use is suspected, neither screening nor detection tests are developed.
Serum steroids were determined by liquid chromatography, tandem mass spectrometry (LC-MS), urine steroids by gas chromatography, mass spectrometry (GC-MS), urine leuprolide and M1 by high resolution LC-MS and urine LH by immunoassay.
Who Took Part
PubMed indexes the participants as young adults, adults and middle-aged adults, men only.
In the 3rd week, men were randomized to either ND injections or no extra treatment.
How the Study Was Run
The researchers set it up as a randomized, open-label and parallel-group study.
Random assignment meant chance, not the researchers, decided who got Leuprolide and who got the comparison, which limits bias.
Nothing was hidden in this open-label Leuprolide study: the participants and staff both knew the treatment.
Groups ran in parallel: each of the participants stayed in one arm throughout.
What Was Measured
While superactive GnRH analog use is suspected, neither screening nor detection tests are developed.
PubMed files the paper under topics including Dihydrotestosterone, Doping in Sports, Estradiol, Leuprolide, Luteinizing Hormone, Nandrolone and Nandrolone Decanoate.
Author keywords: GnRH Analog.
What This Means in Plain Language
The paper is a randomized, open-label and parallel-group study of Leuprolide.
The publication is from 2014 (The Journal of steroid biochemistry and molecular biology), a journal based in England.
More context: the Leuprolide compound page, all human trials.
Our Notes on the Compound
Leuprolide: A 9-amino-acid GnRH analog (Lupron, Eligard) that lowers sex-hormone levels with ongoing use; used in prostate cancer, endometriosis and early puberty.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.