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Constructing a trial as a personal lifestyle change project: participants' experiences in a clinical study for nicotine vaccination.
Plain-language guide to PMID 24581069 (2014): double-blind randomized controlled trial of Therapeutic nicotine (patch, non-peptide).
Key Facts
- PMID
- 24581069
- Journal
- Social science & medicine (1982)
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Wolters A et al. (4 authors)
- DOI
- 10.1016/j.socscimed.2013.12.011
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Therapeutic nicotine (patch, non-peptide).
The purpose of this study was to gain insight into the experiences and dynamics of the involvement of research participants in a randomized clinical trial for nicotine vaccination.
Why It Was Studied
Participants received an experimental nicotine vaccine or a placebo, in addition to quit smoking medication and counseling.
The longitudinal design of this qualitative study allowed them to follow people from their first visit to the trial location until the unblinding of their treatment with either verum or placebo vaccine.
Who Took Part
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Therapeutic nicotine (patch, non-peptide) group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Therapeutic nicotine (patch, non-peptide), so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Therapeutic nicotine (patch, non-peptide) group a baseline to be compared against.
What Was Measured
PubMed files the paper under topics including Life Style, Netherlands, Nicotine, Qualitative Research, Research Subjects, Smoking and Smoking Cessation.
The authors tagged it with the keywords Constructing meaning, Expectations and experiences, Nicotine vaccine, Placebo, Quitting smoking and Randomized clinical trial.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Therapeutic nicotine (patch, non-peptide).
The publication is from 2014 (Social science & medicine (1982)), a journal based in England.
More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.
Our Notes on the Compound
Therapeutic nicotine (patch, non-peptide): Pure nicotine as a signaling tool, separated from smoking and vaping.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.