A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer--the U.K. NCRN Pomi-T study.

What Was Tested

The paper reports a study of Polyphenols, published as a randomized controlled trial.

Although some have been investigated in small, phase II studies, this combination has never been evaluated within an adequately powered randomised controlled trial.

Who Took Part

According to the abstract, 199 men were involved.

By PubMed's age tags, the people studied were middle-aged adults, older adults and people over 80, men only.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Polyphenols and who got the comparison, which limits bias.

Blinding on both sides kept the men and researchers unaware of who received Polyphenols.

The comparison arm used a placebo, so changes seen with Polyphenols could be set against what happens without it.

What Was Measured

Although some have been investigated in small, phase II studies, this combination has never been evaluated within an adequately powered randomised controlled trial.

PubMed files the paper under topics including Brassica, Curcuma, Dietary Supplements, Disease Progression, Kallikreins, Lythraceae and Polyphenols.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Polyphenols in 199 men.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2014 (Prostate cancer and prostatic diseases), a journal based in England.

More context: all human trials.