Effect of vitamin D supplementation on muscle energy phospho-metabolites: a ³¹P magnetic resonance spectroscopy-based pilot study.

What Was Tested

This clinical trial looks at Vitamin D, K2, Magnesium and Zinc.

The present study was proposed to investigate the influence of severe vitamin D deficiency on high-energy metabolite levels in resting skeletal muscle and thereafter, monitor the response after vitamin D supplementation using ³¹P magnetic resonance spectroscopy (MRS).

Why It Was Studied

There are several published reports on the prevalence of low vitamin D levels in otherwise healthy Indian population.

Study was conducted on 19 otherwise healthy subjects but with low serum 25(OH)D levels (<5 ng/ml).

Who Took Part

The abstract describes 19 subjects taking part.

By PubMed's age tags, the people studied were teenagers, young adults and adults, both men and women.

How the Study Was Run

The researchers set it up as a pilot study.

It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.

What Was Measured

There are several published reports on the prevalence of low vitamin D levels in otherwise healthy Indian population.

Study was conducted on 19 otherwise healthy subjects but with low serum 25(OH)D levels (<5 ng/ml).

The subject headings attached to it are Adenosine Triphosphate, Calcifediol, Cholecalciferol, Dietary Supplements, Energy Metabolism, Hyperparathyroidism, Secondary and India.

The authors tagged it with the keywords MRS, oxidative phosphorylation, phosphocreatine and vitamin D deficiency.

What This Means in Plain Language

The paper is a pilot study of Vitamin D, K2, Magnesium and Zinc in 19 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2014 (Endocrine research), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.