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Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials.
Plain-language guide to PMID 24690624 (2014): systematic review of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 24690624
- Journal
- BMJ (Clinical research ed.)
- Year
- 2014
- Study type
- Systematic Review
- Authors
- Theodoratou E et al. (4 authors)
- DOI
- 10.1136/bmj.g2035
What This Paper Covers, in Plain Language
What It Covers
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a systematic review.
To evaluate the breadth, validity, and presence of biases of the associations of vitamin D with diverse outcomes.
Why It Was Studied
Medline, Embase, and screening of citations and references.
Three types of studies were eligible for the umbrella review: systematic reviews and meta-analyses that examined observational associations between circulating vitamin D concentrations and any clinical outcome; and meta-analyses of randomised controlled trials assessing supplementation with vitamin D or active compounds (both established and newer compounds of vitamin D).
Who the Included Studies Covered
Umbrella review of the evidence across systematic reviews and meta-analyses of observational studies of plasma 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D concentrations and randomised controlled trials of vitamin D supplementation.
What Was Measured
Three types of studies were eligible for the umbrella review: systematic reviews and meta-analyses that examined observational associations between circulating vitamin D concentrations and any clinical outcome; and meta-analyses of randomised controlled trials assessing supplementation with vitamin D or active compounds (both established and newer compounds of vitamin D).
The subject headings attached to it are Dietary Supplements, Meta-Analysis as Topic, Observational Studies as Topic, Randomized Controlled Trials as Topic, Systematic Reviews as Topic, Vitamin D and Vitamins.
What This Means in Plain Language
This is a systematic review of Vitamin D, K2, Magnesium and Zinc.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2014 (BMJ (Clinical research ed.)), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.