← Human Trials & Peer-Reviewed Studies
Vitamin B12 status does not influence central motor conduction time in asymptomatic elderly people: a transcranial magnetic stimulation study.
Plain-language guide to PMID 24694205 (2014): randomized controlled trial of Cyanocobalamin (Vitamin B12) in 53 adults.
Key Facts
- PMID
- 24694205
- Journal
- Somatosensory & motor research
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Matamala JM et al. (7 authors)
- DOI
- 10.3109/08990220.2014.897603
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Cyanocobalamin (Vitamin B12).
To test corticospinal tract projections using motor evoked potentials (MEPs) by transcranial magnetic stimulation (TMS) in asymptomatic older adults with low vitamin B12 (B12) levels.
Why It Was Studied
Vitamin B12 deficiency causes neurologic and psychiatric disease, especially in older adults.
Subacute combined degeneration is characterized by damage to the posterior and lateral spinal cord affecting the corticospinal tract.
Who Took Part
According to the abstract, 53 adults were involved.
The age groups tagged for this paper are older adults and people over 80, both men and women.
Cross-sectional study of 53 healthy older adults (>70 years).
How the Study Was Run
In design terms this was a randomized study.
The adults were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.
MEPs were recorded in the abductor pollicis brevis and tibialis anterior muscles, at rest and during slight tonic contraction.
Central motor conduction time (CMCT) was derived from the latency of MEPs and peripheral motor conduction time (PMCT).
Neurophysiological variables were analyzed statistically according to B12 status.
What Was Measured
Topics PubMed links to this paper include Aging, Cross-Sectional Studies, Electromyography, Evoked Potentials, Motor, Hematocrit, Hemoglobins and Mental Status Schedule.
Author keywords: Motor evoked potentials (MEPs), older adults and vitamin B12.
What This Means in Plain Language
The paper is a randomized study of Cyanocobalamin (Vitamin B12) in 53 adults.
Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2014 (Somatosensory & motor research), a journal based in England.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.