Are orange lollies effective in preventing nausea and vomiting related to dimethyl sulfoxide? A multicenter randomized trial

What Was Tested

Researchers studied DMSO (dimethyl sulfoxide, non-peptide solvent) in this randomized controlled trial publication.

Nausea and vomiting (NV) related to DMSO affect patients undergoing auto-SCT despite antiemetic measures.

Who Took Part

The study group was 98 patients.

PubMed indexes the participants as middle-aged adults, both men and women.

Patients were randomized to orange ice lollies, non-citrus ice lollies, and routine treatment (deep breaths) during reinfusion.

Data on NV were collected up to 5 days after infusion; 69/98 patients were randomized: 23 to orange, 21 to non-citrus ice lollies, and 25 to routine treatment.

How the Study Was Run

In design terms this was a randomized, open-label and multicenter study.

The patients were allocated by chance, so the DMSO (dimethyl sulfoxide, non-peptide solvent) group and the comparison group should start out alike.

Nothing was hidden in this open-label DMSO (dimethyl sulfoxide, non-peptide solvent) study: the patients and staff both knew the treatment.

More than one site took part, so the patients came from several places.

The timeline in the abstract includes 5 days.

What Was Measured

The subject headings attached to it are Antiemetics, Aromatherapy, Candy, Citrus sinensis, Dimethyl Sulfoxide, Hematopoietic Stem Cell Transplantation and Ice.

What This Means in Plain Language

The paper is a randomized, open-label and multicenter study of DMSO (dimethyl sulfoxide, non-peptide solvent) in 98 patients over 5 days.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2014 (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer), a journal based in Germany.

More context: the DMSO (dimethyl sulfoxide, non-peptide solvent) compound page, all human trials.