Vitamin D concentration, obesity, and risk of diabetes: a mendelian randomisation study.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a review.

The researchers did a mediation analysis to assess how much of the effect of BMI genotype on risk of diabetes was mediated through plasma 25(OH)D concentration.

Why It Was Studied

Danish Heart Foundation, Copenhagen University Hospital.

Who the Included Studies Covered

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

In this mendelian randomisation study, the researchers genotyped 96 423 white Danes aged 20-100 years from three studies. 5037 of these participants had type 2 diabetes.

All individuals were surveyed for diabetes from 1977 to 2011. 31 040 participants had their plasma 25(OH)D concentration measured and 90 169 had their BMI measured.

How the Review Was Done

The researchers assessed the effects of genetic variation in DHCR7 (related to endogenous production) and CYP2R1 (related to liver conversion) on plasma 25(OH)D concentration, and the effects of variation in FTO, MCR4, and TMEM18 on BMI.

The researchers then assessed the effect of genetic variation in these genes on risk of type 2 diabetes, and the association of measured plasma 25(OH)D concentration and BMI with risk of type 2 diabetes.

What Was Measured

PubMed files the paper under topics including Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Genotype, Obesity, Polymorphism, Single Nucleotide, Risk Factors and Vitamin D.

What This Means in Plain Language

This is a review of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2014 (The lancet. Diabetes & endocrinology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.