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Relationship of vaspin and apelin levels with insulin resistance and atherosclerosis in metabolic syndrome
Plain-language guide to PMID 24736484 (2014): observational study of Apelin in 36 subjects, insulin resistance, prediabetes & type 2 diabetes.
Key Facts
- PMID
- 24736484
- Journal
- Minerva endocrinologica
- Year
- 2014
- Study type
- Observational Study
- Authors
- Karbek B et al. (7 authors)
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Apelin in the context of insulin resistance, prediabetes & type 2 diabetes, published as an observational study.
The researchers aimed to investigate, circulating vaspin, apelin-12 and apelin-36 levels in subjects with metabolic syndrome (MetS) and also to search for the association of vaspin and apelin levels with insulin resistance (IR), high sensitivity C-reactive protein (HsCRP), Carotid Artery Intima-Media Thickness (CIMT) and cardiovascular risk factors.
Who Took Part
The study group was 36 subjects.
The age groups tagged for this paper are adults and middle-aged adults, both men and women.
In this observational case-control study, a total of forty one patients with MetS (30 women and 11 men mean age, 41.3±9.4 years) and thirty nine healthy comparison subjects (27 women and 12 men; mean age, 38.4±6.1 years) were enrolled.
Serum HsCRP, lipid profile, insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated.
How the Study Was Run
Apelin-12, apelin-36 and vaspin serum levels were measured via ELISA.
High-resolution B-mode ultrasonography was performed.
What Was Measured
PubMed files the paper under topics including Adipokines, Apelin, Biomarkers, Body Mass Index, C-Reactive Protein, Carotid Intima-Media Thickness and Case-Control Studies.
What This Means in Plain Language
This is an observational study of Apelin in 36 subjects in people with insulin resistance, prediabetes & type 2 diabetes.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2014 (Minerva endocrinologica), a journal based in Italy.
More context: the Apelin compound page, Insulin resistance, prediabetes & type 2 diabetes research.
Our Notes on the Compound
Apelin: A peptide hormone family that acts on the heart and blood vessels; studied as an infusion in heart and lung research.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.