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Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: randomised trial.
Plain-language guide to PMID 24746976 (2014): randomized controlled trial of Eicosapentaenoic Acid and Carboplatin.
Key Facts
- PMID
- 24746976
- Journal
- Clinical nutrition (Edinburgh, Scotland)
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Sánchez-Lara K et al. (9 authors)
- DOI
- 10.1016/j.clnu.2014.03.006
- Registered trial
- NCT01048970
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Eicosapentaenoic Acid and Carboplatin.
To compare the effect of an oral EPA enriched supplement with an isocaloric diet on nutritional, clinical and inflammatory parameters and HRQL in advanced NSCLC patients.
Why It Was Studied
Eicosapentaenoic acid has been proposed to have anti-inflammatory, anticachectic and antitumoural effects.
Who Took Part
PubMed indexes the participants as teenagers, young adults, adults, middle-aged adults, older adults and people over 80, both men and women.
Patients with advanced NSCLC were randomized to receive diet plus oral nutritional supplement containing EPA (ONS-EPA) or only isocaloric diet (C).
All patients received paclitaxel and cisplatin/carboplatin treatment.
How the Study Was Run
The design is described as randomized.
The participants were allocated by chance, so the Eicosapentaenoic Acid group and the comparison group should start out alike.
Weight, body composition, dietary intake, inflammatory parameters and HRQL were assessed at baseline and after the first and second cycles of chemotherapy.
Response to chemotherapy and survival were evaluated.
What Was Measured
Topics PubMed links to this paper include Appetite, Body Composition, Carboplatin, Carcinoma, Non-Small-Cell Lung, Cisplatin, Dietary Supplements and Eicosapentaenoic Acid.
The authors tagged it with the keywords Health-related quality of life, Non-small cell lung cancer and Nutritional status.
What This Means in Plain Language
The paper is a randomized study of Eicosapentaenoic Acid and Carboplatin.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2014 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.