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Effects of levothyroxine on growth hormone (gh) sensitivity in children with idiopathic short stature.
Plain-language guide to PMID 24857397 (2014): randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 28 boys.
Key Facts
- PMID
- 24857397
- Journal
- Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- García RJ et al. (8 authors)
- DOI
- 10.1016/j.ghir.2014.04.004
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.
The aim of this study is to evaluate the effect of levothyroxine supplementation on GH sensitivity in prepubertal boys with idiopathic short stature (ISS).
Why It Was Studied
The possible relationship between the circulating concentrations of T4 and GH sensitivity has not been elucidated.
Who Took Part
The abstract describes 28 boys taking part.
By PubMed's age tags, the people studied were children, men only.
How the Study Was Run
In design terms this was a randomized and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.
The comparison arm used a placebo, so changes seen with Exogenous HGH, sermorelin & older GHRPs (why they're passed over) could be set against what happens without it.
The researchers selected 28 prepubertal boys with ISS (mean age 8.2±0.5years) and free T4 (Ft4) concentrations between the 3rd and the 25th percentiles (Ft4: 0.8-1.5ng/dl).
What Was Measured
The subject headings attached to it are Body Height, Growth Disorders, Growth Hormone, Insulin-Like Growth Factor I and Thyroxine.
Author keywords: Growth hormone sensitivity, IGF-I, Idiopathic short stature and Levothyroxine.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 28 boys.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2014 (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society), a journal based in Scotland.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.