Vitamin D and endothelial vasodilation in older individuals: data from the PIVUS study.

What Was Tested

This clinical trial looks at Vitamin D, K2, Magnesium and Zinc.

The objective of this study was to examine the association between vitamin D and endothelial function in a large community-based sample of older subjects.

Why It Was Studied

Vitamin D plays a role in a wide range of extraskeletal processes, including vascular function.

Endothelial dysfunction is a predictor of cardiovascular disease, especially in older subjects.

Who Took Part

PubMed indexes the participants as older adults, both men and women.

This cross-sectional study involved 852 community-dwelling men and women aged 70 years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), with complete data on vascular function and 25-hydroxyvitamin D.

How the Study Was Run

The researchers evaluated endothelium-dependent vasodilation by an invasive forearm technique with acetylcholine, endothelium-independent vasodilation by sodium nitroprussiate, flow-mediated vasodilation, and the pulse wave analysis (reflectance index).

Vitamin D levels were measured by chemiluminescence.

The researchers used multivariate regression models adjusted for body mass index (model 1) and for multiple confounders (high-sensitivity C-reactive protein, insulin, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, smoking, sex hormones, season of blood collection, hypertension, diabetes, cardiovascular medications and diseases, statin usage, plasma calcium and calcium intake, PTH, physical exercise, liver and kidney function tests, albumin; model 2).

What Was Measured

However, the relationship between vitamin D levels and indexes of endothelial vasodilation has never been fully addressed in older individuals.

The subject headings attached to it are Acetylcholine, Aging, Biomarkers, Cross-Sectional Studies, Endothelium, Vascular, Forearm and Multivariate Analysis.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2014 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.