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The effects of an oral preparation containing hyaluronic acid (Oralvisc®) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses
Plain-language guide to PMID 24899570 (2015): double-blind randomized controlled trial study of Bradykinin in 40 subjects.
Key Facts
- PMID
- 24899570
- Journal
- Rheumatology international
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Nelson FR et al. (9 authors)
- DOI
- 10.1007/s00296-014-3047-6
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Bradykinin, published as a randomized controlled trial.
The purpose of this study was to determine the effects of an oral preparation containing hyaluronic acid on osteoarthritic knee joint pain and function as well as changes in inflammatory cytokines, bradykinin, and leptin.
The researchers also used heavy water to determine the turnover rates of glycosaminoglycans in synovial fluid.
Why It Was Studied
This was a double-blind, randomized, placebo-controlled study of 40 subjects over a period of 3 months.
Visual analog scale, Western Ontario McMaster pain, and WOMAC function scores were recorded.
Who Took Part
According to the abstract, 40 subjects were involved.
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Bradykinin and who got the comparison, which limits bias.
Neither the subjects nor the staff measuring them knew who was on Bradykinin, so expectations could not easily colour the readings.
Some subjects received a placebo instead of Bradykinin, giving a reference point.
Serum and synovial fluid were measured by enzyme-linked immunosorbent assays for inflammatory cytokines, bradykinin, and leptin.
What Was Measured
Visual analog scale, Western Ontario McMaster pain, and WOMAC function scores were recorded.
The subject headings attached to it are Adjuvants, Immunologic, Bradykinin, Cytokines, Deuterium Oxide, Hyaluronic Acid, Knee Joint and Leptin.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Bradykinin in 40 subjects.
The publication is from 2015 (Rheumatology international), a journal based in Germany.
More context: the Bradykinin compound page, all human trials.
Our Notes on the Compound
Bradykinin: A 9-amino-acid peptide that widens blood vessels and causes swelling; given in research studies of blood flow.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.