Effects of calcium-vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: a randomised placebo-controlled trial.

Plain-language guide to PMID 24962666 (2014): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 56 women.

Key Facts

PMID: 24962666
Journal: Diabetologia
Year: 2014
Study type: Randomized Controlled Trial
Authors: Asemi Z et al. (3 authors)
DOI: 10.1007/s00125-014-3293-x

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

This study was designed to assess the effects of calcium and vitamin D supplementation on the metabolic status of pregnant women with gestational diabetes mellitus (GDM).

Why It Was Studied

The study was supported by a grant (no. 92110) from Kashan University of Medical Sciences.

Who Took Part

The abstract describes 56 women taking part.

The age groups tagged for this paper are teenagers, young adults and adults, women only.

Participants were 56 women with GDM at 24-28 weeks' gestation (18 to 40 years of age).

Subjects were randomly assigned to receive calcium plus vitamin D supplements or placebo.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

This randomised placebo-controlled trial was performed at maternity clinics affiliated to Kashan University of Medical Sciences, Kashan, Iran.

All study participants were blinded to group assignment.

What Was Measured

Topics PubMed links to this paper include Blood Glucose, Calcium, Diabetes, Gestational, Dietary Supplements, Inflammation, Oxidative Stress and Vitamin D.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 56 women.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2014 (Diabetologia), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.