Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.

What It Covers

This meta-analysis looks at Vitamin D, K2, Magnesium and Zinc in the context of low blood pressure and orthostatic hypotension.

The researchers meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements.

Why It Was Studied

British Heart Foundation, UK Medical Research Council, and Academy of Finland.

Who the Included Studies Covered

PubMed indexes the participants as adults and middle-aged adults, both men and women.

In this mendelian randomisation study, the researchers generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which the researchers used as a proxy for 25(OH)D concentration.

The researchers complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium.

What Was Measured

The subject headings attached to it are Body Mass Index, Cholestanetriol 26-Monooxygenase, Cytochrome P450 Family 2, Genetic Predisposition to Disease, Hypertension, Mendelian Randomization Analysis and Oxidoreductases Acting on CH-CH Group Donors.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc in people with low blood pressure and orthostatic hypotension.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2014 (The lancet. Diabetes & endocrinology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Low blood pressure and orthostatic hypotension research.