Effects of magnesium supplements on blood pressure, endothelial function and metabolic parameters in healthy young men with a family history of metabolic syndrome.

Plain-language guide to PMID 24984823 (2014): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc, low blood pressure and orthostatic hypotension.

Key Facts

PMID: 24984823
Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD
Year: 2014
Study type: Randomized Controlled Trial
Authors: Cosaro E et al. (8 authors)
DOI: 10.1016/j.numecd.2014.05.010
Registered trial: NCT01181830

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc in the context of low blood pressure and orthostatic hypotension.

Magnesium plays an important role in the modulation of vascular tone and endothelial function and can regulate glucose and lipid metabolism.

The aim of their study was to evaluate the effect of magnesium supplements on hemodynamic and metabolic parameters in healthy men with a positive family history of MetS or T2DM.

Who Took Part

By PubMed's age tags, the people studied were young adults and adults, men only.

How the Study Was Run

In design terms this was a randomized, double-blind and crossover study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Each person switched between Vitamin D, K2, Magnesium and Zinc and the comparison at some point, usually with a gap in between.

What Was Measured

The subject headings attached to it are Blood Glucose, Blood Pressure, Cholesterol, HDL, Cholesterol, LDL, Diabetes Mellitus, Type 2, Dietary Supplements and Endothelium, Vascular.

The authors tagged it with the keywords Arterial stiffness, Flow mediated dilatation, Magnesium, Metabolic syndrome and Positive family history.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of Vitamin D, K2, Magnesium and Zinc in people with low blood pressure and orthostatic hypotension.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2014 (Nutrition, metabolism, and cardiovascular diseases : NMCD), a journal based in Netherlands.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Low blood pressure and orthostatic hypotension research.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.