Effect of vitamin D replacement on hemoglobin concentration in subjects with concurrent iron-deficiency anemia and vitamin D deficiency: a randomized, single-blinded, placebo-controlled trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc in the context of anemia.

The effect of vitamin D replacement on hemoglobin (Hb) concentration in subjects with concurrent deficiencies of vitamin D and iron is not known.

Who Took Part

The age groups tagged for this paper are young adults, adults and middle-aged adults.

In all subjects, iron deficiency was corrected with parental iron.

How the Study Was Run

The design is described as randomized, single-blind and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Only one side, usually the participants, was kept unaware of whether Vitamin D, K2, Magnesium and Zinc was given.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Other causes of anemia were excluded with appropriate investigation.

The primary end point was a rise in Hb concentration.

What Was Measured

Topics PubMed links to this paper include Anemia, Iron-Deficiency, Case-Control Studies, Cholecalciferol, Erythrocyte Indices, Hemoglobins, Vitamin D and Vitamin D Deficiency.

What This Means in Plain Language

The paper is a randomized, single-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in people with anemia.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (Acta haematologica), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Anemia research.