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Study design and baseline characteristics of participants in the Vitamin D in Vulnerable Adults at the VA (the VIVA Study).
Plain-language guide to PMID 25093912 (2014): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 314 men.
Key Facts
- PMID
- 25093912
- Journal
- Contemporary clinical trials
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Lagari VS et al. (3 authors)
- DOI
- 10.1016/j.cct.2014.07.009
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The researchers describe the study design and the baseline characteristics of the 314 men screened in the VIVA-VA Study (Vitamin D In Vulnerable Adults in the VA), a 2-year, single-site, double-blind, placebo-controlled, randomized clinical trial that enrolled sedentary male veterans ages 65 to 95.
The main inclusion criteria are 25-OH vitamin D (25-OHD) levels between 10 and 30 ng/ml, and a Short Performance Physical Battery (SPPB) score ≤ 9.
Who Took Part
The abstract describes 314 men taking part.
The age groups tagged for this paper are older adults and people over 80, men only.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
The men were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Blinding on both sides kept the men and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
The main inclusion criteria are 25-OH vitamin D (25-OHD) levels between 10 and 30 ng/ml, and a Short Performance Physical Battery (SPPB) score ≤ 9.
The primary outcome of the study is the SPPB.
PubMed files the paper under topics including Florida, Muscle Strength, Sedentary Behavior, United States, United States Department of Veterans Affairs, Vitamin D and Vitamin D Deficiency.
Author keywords: Aging and Physical performance.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 314 men.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2014 (Contemporary clinical trials), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.