Effect of probiotic L. plantarum IS-10506 and zinc supplementation on humoral immune response and zinc status of Indonesian pre-school children.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

A 90-day randomized, double-blind, placebo-controlled, pre-post trial was conducted in four groups of Indonesian children aged 12-24 months: placebo, probiotic, zinc, and a combination of probiotic and zinc (n=12 per group).

Blood and stool samples were collected at baseline and at the end of the study period.

Who Took Part

PubMed indexes the participants as infants and young children, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Fecal sIgA was assessed by ELISA and serum zinc concentrations by ICP-MS.

What Was Measured

The subject headings attached to it are Feces, Immunity, Humoral, Immunoglobulin A, Secretory, Lactiplantibacillus plantarum, Probiotics and Zinc.

Author keywords: Fecal sIgA, Probiotic L. plantarum IS-10506 and Serum zinc.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2014 (Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.