Rationale and design of the Vitamin D and Type 2 Diabetes (D2d) study: a diabetes prevention trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

However, data from long-term trials are lacking.

The Vitamin D and Type 2 Diabetes (D2d) study is a randomized clinical trial designed to examine whether a causal relationship exists between vitamin D supplementation and the development of diabetes in people at high risk for type 2 diabetes.

Who Took Part

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

The primary end point is time to incident diabetes as assessed by laboratory criteria during the study or by adjudication if diagnosed outside of D2d.

Recruitment was initiated at the end of 2013.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

D2d was designed with support from a U34 planning grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

The final protocol was approved by the D2d Research Group, the data and safety monitoring board, and NIDDK.

What Was Measured

The subject headings attached to it are Blood Glucose, Cholecalciferol, Diabetes Mellitus, Type 2, Dietary Supplements, Glycated Hemoglobin and Prediabetic State.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 1 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2014 (Diabetes care), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.