Relationship between brain natriuretic peptide, microalbuminuria, and contrast-induced nephropathy in patients with acute coronary syndrome

What Was Tested

The paper reports a study of BNP (Nesiritide), published as an observational study.

Patients may develop kidney failure because of the contrast agent given during coronary angiography.

In their study, the researchers aimed to investigate whether there is a relationship between subclinical renal (indicated by microalbuminuria) and/or cardiac (indicated by the height of the BNP) dysfunction between the development of contrast-induced nephropathy on patients undergoing angiography due to acute coronary syndrome.

Blood samples were collected from 145 patients without microalbuminuria and 25 patients with microalbuminuria to determine their BNP levels before coronary angiography.

Who Took Part

According to the abstract, 170 patients were involved.

PubMed indexes the participants as middle-aged adults, both men and women.

A total of 170 patients hospitalized with a diagnosis of acute coronary syndrome in the coronary care unit were included in this study.

The patients' urea and creatinine levels were examined before and 72 h after coronary angiography.

How the Study Was Run

This is an observational prospective cohort study.

Statistical analysis was performed using Kolmogorov-Smirnov test, Mann-Whitney U test, independent samples t-test and the chi-square test.

What Was Measured

Topics PubMed links to this paper include Acute Coronary Syndrome, Albuminuria, Cohort Studies, Contrast Media, Coronary Angiography, Kidney Diseases and Natriuretic Peptide, Brain.

What This Means in Plain Language

This is an observational study of BNP (Nesiritide) in 170 patients.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2014 (Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology), a journal based in Turkey.

More context: the BNP (Nesiritide) compound page, all human trials.