Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not impact clinical outcomes: a randomized, double-blind, placebo-controlled trial

What Was Tested

Researchers studied hCG (human chorionic gonadotropin) in the context of endometriosis in this randomized controlled trial publication.

To determine whether endometrial hCG infusion at the time of human blastocyst transfer impacts implantation rates.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

Patients undergoing ET were randomized into either a treatment or a control group.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this hCG (human chorionic gonadotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind hCG (human chorionic gonadotropin) study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the hCG (human chorionic gonadotropin) group a baseline to be compared against.

Infertile couples with the female partner less than 43 years old (n = 300) undergoing fresh or frozen ET of one or two blastocysts.

The control group received a sham infusion of ET media.

Infusions were done using a separate catheter less than 3 minutes before actual ET.

What Was Measured

The subject headings attached to it are Blastocyst, Chorionic Gonadotropin, Embryo Implantation, Embryo Transfer, Endometrium, Freezing and Infertility.

The authors tagged it with the keywords hCG, implantation rate, intrauterine hCG and pregnancy rate.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of hCG (human chorionic gonadotropin) in people with endometriosis.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2014 (Fertility and sterility), a journal based in United States.

More context: the hCG (human chorionic gonadotropin) compound page, Endometriosis research.