Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: a one-year pilot randomized controlled trial in adults with severe burns.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia.

Vitamin D pleiotropic effects may influence bone and muscle health.

The aim of this pilot study was to assess effects of a cholecalciferol (VD3) supplementation and an optimized calcium (Ca) regimen on vitamin D (VD) status, bone and muscle health during sequelar stage of burn injury.

Who Took Part

PubMed indexes the participants as adults and middle-aged adults, both men and women.

Fifteen adults with thermal burns dating from 2 to 5 years were randomized into two groups.

How the Study Was Run

The design is described as randomized, placebo-controlled and pilot.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.

VD status and bone remodeling markers were assessed every 3 months.

Knee muscle strength and bone mineral density were, respectively, assessed using isokinetic dynamometry and dual X-ray absorptiometry at initiation (M0) and completion (M12) of the protocol.

What Was Measured

Topics PubMed links to this paper include Bone Density, Bone Density Conservation Agents, Burns, Calcium, Cholecalciferol, Dietary Supplements and Knee Joint.

The authors tagged it with the keywords Bone mineral density, Burn injury, Isokinetic dynamometry, Muscle strength and Vitamin D.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and pilot study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2015 (Burns : journal of the International Society for Burn Injuries), a journal based in Netherlands.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.