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Effects of vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation on muscle function and oxidative stress biomarkers in patients with facioscapulohumeral dystrophy: a double-blind randomized controlled clinical trial.
Plain-language guide to PMID 25246239 (2015): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 25246239
- Journal
- Free radical biology & medicine
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Passerieux E et al. (14 authors)
- DOI
- 10.1016/j.freeradbiomed.2014.09.014
- Registered trial
- NCT01596803
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, both men and women.
Adult patients with FSHD (n=53) were enrolled at Montpellier University Hospital (France) in a randomized, double-blind, placebo-controlled pilot clinical trial.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and pilot.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
What Was Measured
The subject headings attached to it are Ascorbic Acid, Dietary Supplements, Gait, Gluconates, Muscle Contraction, Muscle, Skeletal and Muscular Dystrophy, Facioscapulohumeral.
Author keywords: Antioxidants, Facioscapulohumeral muscular dystrophy (FSHD), Oxidative stress, Physical performance and Radical oxygen species.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The publication is from 2015 (Free radical biology & medicine), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.