Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).

To determine the effect of vitamin D supplementation on winter-related AD.

Who Took Part

By PubMed's age tags, the people studied were young children, children and teenagers, both men and women.

The researchers performed a randomized, double-blind, placebo-controlled trial of Mongolian children with winter-related AD (clinicaltrials.gov identifier: NCT00879424).

All children and parents received emollient and patient education about AD and basic skin care.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Baseline eligibility included age 2 to 17 years, AD score 10 to 72 using the Eczema Area and Severity Index (EASI), and winter-related AD (eg, history of AD worsening during the fall-to-winter transition).

The main outcomes were changes in EASI score and in Investigator's Global Assessment.

What Was Measured

The subject headings attached to it are Cholecalciferol, Dermatitis, Atopic, Dietary Supplements, Disease Progression, Mongolia, Seasons and Vitamin D.

Author keywords: Randomized controlled trial, atopic dermatitis, children, nutritional supplement and winter.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2014 (The Journal of allergy and clinical immunology), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.