Comparison of the hemostatic effects of a levonorgestrel-releasing intrauterine system and leuprolide acetate in women with endometriosis: a randomized clinical trial

What Was Tested

Researchers studied Leuprolide in the context of endometriosis in this randomized controlled trial publication.

The objective of this study was to compare the hemostatic effects of two treatments widely prescribed to women with endometriosis: the levonorgestrel intrauterine system (LNG-IUS) and the gonadotropin-releasing hormone analog (GnRHa) leuprolide acetate.

Why It Was Studied

The hemostatic and inflammatory systems may activate each other.

Who Took Part

The abstract describes 44 women taking part.

By PubMed's age tags, the people studied were teenagers, young adults and adults, women only.

In this randomized open-label controlled trial, 44 women with endometriosis were randomly allocated to one of two groups: 22 women were assigned to use LNG-IUS and 22 to use GnRHa.

The assessed variables were D-dimers, fibrinogen, prothrombin time, activated partial thromboplastin time, coagulation factors (F) II, V, VII, VIII, IX, X, and XI, antithrombin (AT), protein C, free protein S, tissue plasminogen activator (t-PA), α2-antiplasmin, thrombin-antithrombin complex, and prothrombin fragment 1+2.

How the Study Was Run

The researchers set it up as a randomized and open-label study.

Random assignment meant chance, not the researchers, decided who got Leuprolide and who got the comparison, which limits bias.

Being open-label, the Leuprolide study did not mask who received what.

All variables were assessed before treatment and six months after treatment onset.

What Was Measured

The subject headings attached to it are Blood Coagulation, Contraceptive Agents, Female, Endometriosis, Fertility Agents, Female, Hemostasis, Hemostatics and Leuprolide.

The authors tagged it with the keywords GnRH agonist, Levonorgestrel and Progesterone-releasing intrauterine device.

What This Means in Plain Language

The paper is a randomized and open-label study of Leuprolide in 44 women in people with endometriosis.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2014 (Thrombosis research), a journal based in United States.

More context: the Leuprolide compound page, Endometriosis research.