Effects of a soy-based dietary supplement compared with low-dose hormone therapy on the urogenital system: a randomized, double-blind, controlled clinical trial.

What Was Tested

Researchers studied Copper (Supplement) in this randomized controlled trial publication.

Transvaginal sonography was performed to evaluate endometrial thickness.

Who Took Part

The study group was 60 women.

The age groups tagged for this paper are adults and middle-aged adults, women only.

Urinary, vaginal, and sexual complaints were evaluated using the urogenital subscale of the Menopause Rating Scale.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Copper (Supplement) and who got the comparison, which limits bias.

As a double-blind Copper (Supplement) study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Copper (Supplement) could be set against what happens without it.

Vaginal maturation value was calculated.

Genital bleeding pattern was assessed.

Statistical analysis was performed using χ(2) test, Fisher's exact test, paired Student's t test, Kruskal-Wallis test, Kruskal-Wallis nonparametric test, and analysis of variance.

For intergroup comparisons, Kruskal-Wallis nonparametric test (followed by Mann-Whitney U test) was used.

What Was Measured

PubMed files the paper under topics including Dietary Supplements, Estradiol, Estrogen Replacement Therapy, Isoflavones, Norethindrone, Phytotherapy and Postmenopause.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement) in 60 women.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (Menopause (New York, N.Y.)), a journal based in United States.

More context: the Copper (Supplement) compound page, all human trials.