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Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: a randomized, double blind, placebo-controlled study.
Plain-language guide to PMID 25461390 (2015): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 10 subjects.
Key Facts
- PMID
- 25461390
- Journal
- Cytokine
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Barker T et al. (9 authors)
- DOI
- 10.1016/j.cyto.2014.09.012
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D.
Why It Was Studied
Fasting blood samples were obtained before (Baseline, Bsl) and 35-days after (35-d) supplementation.
Who Took Part
According to the abstract, 10 subjects were involved.
PubMed indexes the participants as adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The subjects were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the subjects nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
Serum 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)D), cytokines, and intact parathyroid hormone with calcium were measured in each blood sample.
What Was Measured
The subject headings attached to it are Body Mass Index, Calcium, Cholecalciferol, Cytokines, Dietary Supplements, Fasting and Isometric Contraction.
Author keywords: 1,25-Dihydroxyvitamin D, Interferon-γ, Interleukin-10 and Serum 25-hydroxyvitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 10 subjects.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2015 (Cytokine), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.