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Zinc supplementation reduced DNA breaks in Ethiopian women.
Plain-language guide to PMID 25491347 (2015): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 25491347
- Journal
- Nutrition research (New York, N.Y.)
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Joray ML et al. (8 authors)
- DOI
- 10.1016/j.nutres.2014.10.006
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Assessment of zinc status remains a challenge largely because serum/plasma zinc may not accurately reflect an individual's zinc status.
The comet assay, a sensitive method capable of detecting intracellular DNA strand breaks, may serve as a functional biomarker of zinc status.
Who Took Part
PubMed indexes the participants as teenagers, young adults, adults and middle-aged adults, women only.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
Assessment of zinc status remains a challenge largely because serum/plasma zinc may not accurately reflect an individual's zinc status.
The researchers hypothesized that effects of zinc supplementation on intracellular DNA damage could be assessed from samples collected in field studies in Ethiopia using the comet assay.
Topics PubMed links to this paper include Comet Assay, DNA Breaks, Dietary Supplements, Endpoint Determination, Ethiopia, Leukocytes, Mononuclear and Orosomucoid.
Author keywords: Biomarkers, Randomized controlled trial, Women and Zinc deficiency.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The publication is from 2015 (Nutrition research (New York, N.Y.)), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.