Comparative evaluation of serum superoxide dismutase and glutathione levels in periodontally diseased patients: an interventional study

What Was Tested

Researchers studied Glutathione in the context of gum disease (periodontal) & oral health in this clinical trial publication.

The present study was designed to estimate and compare the superoxide dismutase (SOD) and glutathione (GSH) levels in the serum of periodontitis, gingivitis, and healthy individuals before and after nonsurgical periodontal therapy.

Why It Was Studied

Periodontal disease is an immune-inflammatory disease characterized by connective tissue breakdown, loss of attachment, and alveolar bone resorption.

Under normal physiological conditions, a dynamic equilibrium is maintained between the reactive oxygen species (ROS) and antioxidant defense capacity.

Who Took Part

The abstract describes 75 subjects taking part.

PubMed tags the participants as both men and women.

The present study was conducted in the Department of Periodontics, A.

The study was designed as a single blinded interventional study comprising 75 subjects, inclusive of both sexes and divided into three groups of 25 patients each.

How the Study Was Run

The design is described as single-blind.

In this single-blind Glutathione study one party knew the assignments and the other did not.

Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore.

Patients were categorized into chronic periodontitis, gingivitis, and healthy.

The severity of inflammation was assessed using gingival index and pocket probing depth.

Biochemical analysis was done to estimate the SOD and GSH levels before and after nonsurgical periodontal therapy.

RESULTS obtained were then statistically analyzed using ANOVA test and paired t-test.

What Was Measured

Topics PubMed links to this paper include Chronic Periodontitis, Free Radical Scavengers, Gingivitis, Glutathione, Periodontal Attachment Loss, Periodontal Debridement and Periodontal Index.

What This Means in Plain Language

The paper is a single-blind study of Glutathione in 75 subjects in people with gum disease (periodontal) & oral health.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2014 (Indian journal of dental research : official publication of Indian Society for Dental Research), a journal based in India.

More context: the Glutathione compound page, Gum disease (periodontal) & oral health research.