Effectiveness of angiotensin II receptor antagonists in a cohort of Dutch patients with type 2 diabetes mellitus (ZODIAC-14).

What Was Tested

Researchers studied Angiotensin Receptor Antagonists in this observational study publication.

There is limited evidence with respect to the between-group effects of various angiotensin receptor blockers (ARBs) on blood pressure and albuminuria in patients with type 2 diabetes mellitus.

Who Took Part

The study group was 24,940 patients.

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

In 2007, 24 940 primary care patients with type 2 diabetes mellitus participated in the Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) study, a prospective observational cohort study.

Patients were included in the current study if they were prescribed an ARB in 2007 and if 1-year follow-up data were available.

How the Study Was Run

The final study population comprised 3610 patients.

Multivariate mixed-model analyses were performed to estimate effects of the various ARBs on SBP and albuminuria.

Stratified subgroup analyses were performed according to baseline hypertension and albuminuria.

What Was Measured

Topics PubMed links to this paper include Albuminuria, Angiotensin Receptor Antagonists, Diabetes Mellitus, Type 2, Hypertension and Netherlands.

Author keywords: albuminurie, angiotensin II receptor antagonists, antagonistes des récepteurs de l'angiotensine II, diabète sucré de type 2, observational studies and type 2 diabetes mellitus.

What This Means in Plain Language

This is an observational study of Angiotensin Receptor Antagonists in 24,940 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (Canadian journal of diabetes), a journal based in Canada.

More context: all human trials.