← Human Trials & Peer-Reviewed Studies
Antioxidative capacity of a dietary supplement on retinal hemodynamic function in a human lipopolysaccharide (LPS) model.
Plain-language guide to PMID 25525163 (2014): double-blind randomized controlled trial of Antioxidants in 43 subjects.
Key Facts
- PMID
- 25525163
- Journal
- Investigative ophthalmology & visual science
- Year
- 2014
- Study type
- Randomized Controlled Trial
- Authors
- Told R et al. (11 authors)
- DOI
- 10.1167/iovs.14-15581
- Registered trial
- NCT00914576
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Antioxidants.
Who Took Part
The study group was 43 subjects.
PubMed indexes the participants as teenagers, young adults and adults, both men and women.
A total of 43 healthy subjects was included in this randomized, double masked, placebo-controlled parallel group study.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and parallel-group study.
The subjects were allocated by chance, so the Antioxidants group and the comparison group should start out alike.
As a double-blind Antioxidants study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the Antioxidants group a baseline to be compared against.
Groups ran in parallel: each of the subjects stayed in one arm throughout.
The researchers hypothesized that the abnormal O2-induced retinal red blood cell (RBC) flow response can be modulated by a different formulation (vitamin C, E, and zinc, lutein/zeaxanthin, selenium, taurine, Aronia extract, and omega-3 free fatty acids).
What Was Measured
PubMed files the paper under topics including Antioxidants, Dietary Supplements, Healthy Volunteers, Hemodynamics, Laser-Doppler Flowmetry, Lipopolysaccharides and Macular Degeneration.
The authors tagged it with the keywords endotoxin model, red blood cell flow, retinal blood flow, retinal hemodynamic function, white blood cell flow and young healthy subjects.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Antioxidants in 43 subjects.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2014 (Investigative ophthalmology & visual science), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.