Vitamin D supplementation and testosterone concentrations in male human subjects.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

A possible association between serum 25-hydroxyvitamin D and testosterone levels has been reported; however, contradictory results have emerged.

Who Took Part

The study group was 1, subjects.

The age groups tagged for this paper are young adults, adults, middle-aged adults, older adults and people over 80, men only.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some subjects received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Blood was drawn at baseline, after 3 and 6 weeks.

Blood was drawn at baseline, after 8 and 16 weeks.

Blood was drawn at baseline, after 8 and 16 weeks.

Serum 25-hydroxyvitamin D levels were measured using LC-MS/MS or radioimmunoassay.

Testosterone levels were measured using a 2nd generation immunoassay.

What Was Measured

PubMed files the paper under topics including Cholecalciferol, Cohort Studies, Dietary Supplements, Emigrants and Immigrants, Heart Failure, Netherlands and Nursing Homes.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 1, subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2015 (Clinical endocrinology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.