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Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236).
Plain-language guide to PMID 25595352 (2015): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 362 women.
Key Facts
- PMID
- 25595352
- Journal
- Gene
- Year
- 2015
- Study type
- Randomized Controlled Trial
- Authors
- Laczmanski L et al. (11 authors)
- DOI
- 10.1016/j.gene.2015.01.022
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene.
Why It Was Studied
Vitamin D co-regulates the synthesis of sex hormones in part by interaction with its nuclear receptor.
Who Took Part
According to the abstract, 362 women were involved.
The age groups tagged for this paper are older adults and people over 80, both men and women.
Rs10735810, rs1544410, rs7975232, and rs731236 polymorphisms of VDR, the serum sex hormone level, free estrogen index (FEI) and free androgen index (FAI) as well as vitamin D, were evaluated in 766 persons (362 women and 404 men) selected from 5695 Polish population, aged 65-90years from the PolSenior survey.
How the Study Was Run
The design is described as randomized.
The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
What Was Measured
The subject headings attached to it are Estrogens, Heterozygote, Poland, Polymorphism, Genetic, Receptors, Calcitriol, Testosterone and Vitamin D.
The authors tagged it with the keywords Aging, FAI, Testosterone level, VDR polymorphism and Vitamin D level.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 362 women.
With several hundred people or more, it is a fairly large study for this kind of research.
Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2015 (Gene), a journal based in Netherlands.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.